Lucidas (SPRYCEL)20mg is a kinase inhibitor indicated for the treatment of
1. newly diagnosed adults with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase.
2. adults with chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with resistance or intolerance to prior therapy including imatinib.
3. adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance or intolerance to prior therapy.
4. pediatric patients with Ph+ CML in chronic phase
DOSAGE AND ADMINISTRATION
1. Chronic phase CML in adults: 100 mg once daily.
2. Accelerated phase CML, myeloid or lymphoid blast phase CML, or Ph+ ALL in adults: 140 mg once daily.
3. Chronic phase CML in pediatrics: starting dose based on body weight.
4. Administer orally, with or without a meal. Do not crush, cut, or chew tablets.