Herduo (lapatinib 250mg)’s brand name is TYKERB® by Novartis Pharmaceuticals. Herduo (lapatinib 250mg) is a generic kinase inhibitor indicated for Breast Cancer medicine from Natco, which is a listed and the one of the largest generic pharmaceutical manufacturer in India.
Tykerb Cost & Price (Generic):
Tykerb (Lapatinib 250mg)’s price in United States is $ 7650，Generic lapatinib price in India is only 10% of the Tykerb price in US. Tykerb cost per pill in India is only 5 dolloars.
The following is the details of Lapatinib 250mg indication:
1. capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress human epidermal growth factor receptor 2 (HER2) and who have received prior therapy including an anthracycline, a taxane, and trastuzumab. Limitations of Use: Patients should have disease progression on trastuzumab prior to initiation of treatment with TYKERB in combination with capecitabine.
2.letrozole for the treatment of postmenopausal women with hormone receptor- positive metastatic breast cancer that overexpresses the HER2 receptor for whom hormonal therapy is indicated. TYKERB in combination with an aromatase inhibitor has not been compared to a trastuzumab-containing chemotherapy regimen for the treatment of metastatic breast cancer.
DOSAGE AND ADMINISTRATION
The recommended dosage of TYKERB for advanced or metastatic breast cancer is 1,250 mg (5 tablets) given orally once daily on Days 1-21 continuously in combination with capecitabine 2,000 mg/m2/day (administered orally in 2 doses approximately 12 hours apart) on Days 1-14 in a repeating 21-day cycle.
The recommended dose of TYKERB for hormone receptor-positive, HER2-positive metastatic breast cancer is 1,500 mg (6 tablets) given orally once daily continuously in combination with letrozole. When TYKERB is coadministered with letrozole, the recommended dose of letrozole is 2.5 mg once daily.
1.TYKERB should be taken at least one hour before or one hour after a meal. However, capecitabine should be taken with food or within 30 minutes after food.
2.TYKERB should be taken once daily. Do not divide daily doses of TYKERB.
3.Modify dose for cardiac and other toxicities, severe hepatic impairment, diarrhea, and CYP3A4 drug interactions.
Long term side effects of Tykerb：
TYKERB may cause serious side effects, including: • heart problems, including decreased pumping of blood from the heart and an abnormal heartbeat. Signs and
symptoms of an abnormal heartbeat include: o feeling like your heart is pounding or racing o feeling lightheaded o dizziness o shortness of breath o tiredness
Your healthcare provider should check your heart function before you start taking TYKERB and during treatment.
1.liver problems. Liver problems can be severe and deaths have happened. Signs and symptoms of liver problems include: o itching o yellowing of your skin or the white part of your eyes o dark urine o pain or discomfort in the right upper stomach area Your healthcare provider should do blood tests to check your liver before you start taking TYKERB and during treatment.
2.diarrhea. Diarrhea is common with TYKERB and may sometimes be severe. Severe diarrhea can cause loss of body fluid (dehydration) and some deaths have happened. Call your healthcare provider right away if you have a change in bowel pattern or if you have severe diarrhea. Follow your healthcare provider’s instructions for what to do to help prevent or treat diarrhea.
3.lung problems. Symptoms of a lung problem with TYKERB include a cough that will not go away or shortness of breath.
4.severe skin reactions. TYKERB may cause severe skin reactions. Tell your healthcare provider right away if you develop a skin rash, red skin, blistering of the lips, eyes, or mouth, peeling of the skin, fever, or any combination of these. As severe skin reactions can be life-threatening, your healthcare provider may tell you to stop taking TYKERB. Call your healthcare provider right away if you have any of the signs or symptoms of the serious side effects listed above.